Genomic landscape and survival analysis of ctDNA "neo- RAS wild-type" patients with originally RAS mutant metastatic colorectal cancer.

Chiara Nicolazzo,Valentina Magri,Luca Marino,Francesca Belardinilli,Federica Di Nicolantonio,Gianluigi De Renzi,Salvatore Caponnetto,Michela De Meo,Giuseppe Giannini,Daniele Santini,Enrico Cortesi,Paola Gazzaniga

Frontiers in oncology（2023）

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摘要

De-novo-targetable mutations occured in a large percentage of "neo- wild-type", being the most commonly detected. mutation clearance in ctDNA is associated with long- term improvement of overall survival.

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关键词

RAS mutant colorectal cancer,bevacizumab,circulating tumor DNA,neo-RAS,survival

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