Uncovering the significance of expanded CD8 + large granular lymphocytes in inclusion body myositis: Insights into T cell phenotype and functional alterations, and disease severity.

Emily McLeish,Anuradha Sooda,Nataliya Slater, Barbara Kachigunda,Kelly Beer,Shereen Paramalingam,Phillipa J Lamont,Abha Chopra,Frank Louis Mastaglia,Merrilee Needham,Jerome David Coudert

Frontiers in immunology（2023）

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摘要

Altogether, these results suggest that T-LGL expansion occurring in IBM patients is correlated with exacerbated immune dysregulation and increased disease burden.

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关键词

KLRG1,T cell large granular lymphocytes,inclusion body myositis,inhibitory natural killer receptors,senescence

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