Molecular Profiling of High-Level Athlete Skeletal Muscle after Acute Endurance or Resistance Exercise – A Systems Biology Approach
Molecular metabolism(2023)
摘要
SUMMARY Life-long high-level exercise training leads to improvements in physical performance and multi-tissue adaptation following changes in molecular pathways. While skeletal muscle baseline differences between exercise-trained and untrained individuals have been previously investigated, it remains unclear how acute exercise multi-omics are influenced by training history. We recruited and extensively characterized 24 individuals categorized as endurance athletes, strength athletes or control subjects. Multi-omics profiling was performed from skeletal muscle before and at three time-points after endurance or resistance exercise sessions. Timeseries multi-omics analysis revealed distinct differences in molecular processes such as fatty- and amino acid metabolism and for transcription factors such as HIF1A and the MYF-family between both exercise history and acute form of exercise. Furthermore, we found a “transcriptional specialization effect” by transcriptional narrowing and intensification. Finally, we performed multi-omics network analysis and clustering, providing a novel resource of skeletal muscle transcriptomic and metabolomic profiling in highly trained and untrained individuals.
更多查看译文
关键词
Molecular exercise effects,Metabolomics,Multi-omics,Human,Systems biology,Athletes
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要