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Pathological Bile Acid Concentrations in Chronic Cholestasis Cause Adipose Mitochondrial Defects.

Weinan Zhou,Philip VanDuyne,Chi Zhang, Yushan Liu,Ryan Riessen,Maribel Barragan,Blair M. Rowitz,Margarita Teran-Garcia,Stephen A. Boppart,Sayeepriyadarshini Anakk

JHEP REPORTS（2023）

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Abstract
Impact and Implications: We uncover a detrimental effect of chronic bile acid (BA) overload on adipose mitochondrial function. Pathological concentration of different BAs reduces the expression of distinct genes involved in energy expenditure, which can be mitigated with pharmacological UCP1 activation.
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Key words
Bile acid,Cholestasis,Adipose tissue,Mitochondrial function
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