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Multi-ancestry GWAS deciphers genetic architecture of abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target

Tanmoy Roychowdhury,Derek Klarin,Michael G Levin,Joshua M Spin,Yae Hyun Rhee,Alicia Deng,Colwyn A Headley,Ida Surakka,Noah L Tsao,Corry Gellatly,Verena Zuber,Fred Shen,Whitney E Hornsby,Ina Holst Laursen,Shefali S Verma,Adam E Locke,Gudmundur Einarsson,Gudmar Thorleifsson,Sarah E Graham,Ozan Dikilitas,Jack W Pattee,Renae L Judy,Ferran Pauls-Verges,Jonas B Nielsen,Brooke N Wolford,Ben M Brumpton,Jaume Dilmé,Olga Peypoch,Laura Calsina Juscafresa,Todd L Edwards,Dadong Li,Karina Banasik,Søren Brunak,Rikke L Jacobsen,Minerva T Garcia-Barrio,Jifeng Zhang,Lars M Rasmussen,Regent Lee,Ashok Handa,Anders Wanhainen,Kevin Mani,Jes S Lindholt,Lasse M Obel,Ewa Strauss,Grzegorz Oszkinis,Christopher P Nelson,Katie Saxby,Joost A van Herwaarden,Sander W van der Laan,Jessica van Setten,Mercedes Camacho,Frank M Davis,Rachael Wasikowski,Lam C Tsoi,Johann E Gudjonsson,Jonathan L Eliason,Dawn M Coleman,Peter K Henke,Santhi K Ganesh,Y Eugene Chen,Weihua Guan,James S Pankow,Nathan Pankratz,Ole B Pedersen,Christian Erikstrup,Weihong Tang,Kristian Hveem,Daniel Gudbjartsson,Solveig Gretarsdottir,Unnur Thorsteinsdottir,Hilma Holm,Kari Stefansson,Manuel A Ferreira, Aris Baras,Iftikhar J Kullo,Marylyn D Ritchie,Alex H Christensen,Kasper K Iversen,Nikolaj Eldrup,Henrik Sillesen,Sisse R Ostrowski,Henning Bundgaard,Henrik Ullum,Stephen Burgess,Dipender Gill,Katherine Gallagher,Maria Sabater-Lleal, DiscovEHR,Regeneron Genetics Center, UK Aneurysm Growth Study,DBDS Genomic Consortium,VA Million Veteran Program,Gregory T Jones,Matthew J Bown,Philip S Tsao,Cristen J Willer,Scott M Damrauer

medrxiv（2022）

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