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Genes associated with cellular senescence favor melanoma prognosis by stimulating immune responses in tumor microenvironment.

Xiaofeng Liang,Xiaobing Lin,Zien Lin,Weiyi Lin,Zhishen Peng,Shanshan Wei

Computers in biology and medicine（2023）

Cited 1|Views6
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Abstract
Genes associated with cellular senescence favor SKCM prognosis by stimulating immune responses in TME. Patients with high expression of cellular senescence associated genes in the TME might have better benefit from ICI immunotherapy. Cellular senescence functions as a pro-tumor agent in mesenchymal cells and needs further study.
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Key words
Cellular senescence,Machine learning,Prognostic genes,Risk model,Skin cutaneous melanoma,Tumor microenvironment
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