Fig. S3 from A miR-29b Byproduct Sequence Exhibits Potent Tumor-Suppressive Activities via Inhibition of NF-κB Signaling in <i>KRAS</i>-Mutant Colon Cancer Cells

Supplementary Figure S3. Hypothetical and conclusive schematic illustration of each signaling pathway. (A) A hypothetical schematic illustration of each signaling pathway. Could a novel anti-tumor RNA sequence named "MIRTX" directly target PIK3R1 and CXCR2, leading to suppression of NF-κB and PI3K/AKT/mTOR signaling pathways in KRAS mutant CRC? (B) A conclusive scheme of each signaling pathway. A novel anti-tumor small RNA sequence named "MIRTX" directly targets PIK3R1 and CXCR2, leading to suppression of NF-κB signaling pathways in KRAS mutant CRC, triggering apoptosis; however, PI3K/AKT/mTOR pathway was maintained, possibly by a feedback regulatory mechanism.