Supplementary Table 1 from Fibulin-3 Promotes Glioma Growth and Resistance Through a Novel Paracrine Regulation of Notch Signaling

Bin Hu,Mohan S. Nandhu,Hosung Sim,Paula A. Agudelo-Garcia,Joshua C. Saldivar,Claire E. Dolan,Maria E. Mora,Gerard J. Nuovo,Susan E. Cole,Mariano S. Viapiano

openalex（2023）

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PDF file - 64K, List of antibodies used

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Fibrillin-1

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Pretraining has recently greatly promoted the development of natural language processing (NLP)
We show that M6 outperforms the baselines in multimodal downstream tasks, and the large M6 with 10 parameters can reach a better performance
We propose a method called M6 that is able to process information of multiple modalities and perform both single-modal and cross-modal understanding and generation
The model is scaled to large model with 10 billion parameters with sophisticated deployment, and the 10 -parameter M6-large is the largest pretrained model in Chinese
Experimental results show that our proposed M6 outperforms the baseline in a number of downstream tasks concerning both single modality and multiple modalities We will continue the pretraining of extremely large models by increasing data to explore the limit of its performance

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【要点】：该论文揭示了纤维蛋白-3（Fibulin-3）通过新型的旁分泌调控Notch信号通路，促进胶质瘤生长和抗药性。

【方法】：研究采用分子生物学方法，包括免疫组化、实时定量PCR、细胞培养和蛋白质印迹等，探索Fibulin-3与Notch信号通路之间的相互作用。

【实验】：实验使用了多种细胞系和动物模型，通过体外和体内实验验证了Fibulin-3的作用机制。具体数据集名称未在摘要中提及，但论文中可能涉及了如TCGA（The Cancer Genome Atlas）等数据库的数据。实验结果表明，Fibulin-3在胶质瘤细胞中的表达与肿瘤的生长和抗药性密切相关。