Supplementary Figures 1 - 9 from ETS Transcription Factor ESE1/ELF3 Orchestrates a Positive Feedback Loop That Constitutively Activates NF-κB and Drives Prostate Cancer Progression

PDF file - 782K, ESE1/ELF3 overexpression in primary prostate tumors (S1); Generation of stable ESE-1/ELF3 over-expressing prostate cancer cell lines (S2); Level of ESE1/ELF3 in prostate tumor xenografts (S3); Network interactions between ESE1/ELF3-induced genes and ETS transcription factors (S4); Position of ETS binding sites identified by computational analysis using Motiviz (S5); Convergence between the transcriptional program induced in IL-1B transgenic mice and ESE1/ELF3 overexpressing 22RVI cells (S6); Reciprocal regulatory loops between ESE1/ELF3 and NFKB (S7); Immunofluorescence microscopy for detection of ESE1/ELF3, p50, p65, and nuclei (S8); Kaplan-Meyer analysis of overall survival of prostate cancer patients from the TMA cohort subdivided according to ESE1/ELF3 and p50/p65 nuclear expression (S9).