Supplemental Figures S1-S7 from A TDO2-AhR Signaling Axis Facilitates Anoikis Resistance and Metastasis in Triple-Negative Breast Cancer

Differentially expressed genes in TNBC cells grown in attached vs. forced suspension conditions (S1); Increasing intracellular and secreted metabolites by unsupervised metabolomic analysis (S2); Increased expression of kynurenine pathway enzymes is unique to TNBC cell lines and facilitates endogenous activation of AhR (S3); AhR pathway components are differentially expressed in attached versus suspended conditions (S4); Analysis of TDO2 Inhibitor GI50 in TNBC cell lines (S5); Knockdown of TDO2 and AhR decrease proliferation of TNBC cells (S6); IDO1 expression in breast cancer clinical samples (S7).