Ursolic Acid Ameliorates DNCB-induced Atopic Dermatitis-Like Symptoms in Mice by Regulating TLR4/NF-κB and Nrf2/HO-1 Signaling Pathways.

Zhehuan Wang,Huiru Zhang,Caihong Qi,Hui Guo,Xiangyue Jiao,Jia Yan,Yifei Wang,Qiangsheng Li,Mingming Zhao,Xinhao Guo,Baoluo Wan,Xiaotian Li

INTERNATIONAL IMMUNOPHARMACOLOGY（2023）

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摘要

•UA attenuated AD-like lesions in DNCB-induced AD mice.•UA alleviated DNCB-induced mast cell infiltration.•UA inhibited inflammatory response and oxidative stress in AD mice.•UA acted via inhibition of TLR4/NF-κB pathway and activation of Nrf2/HO-1 pathway.

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关键词

Atopic dermatitis,Ursolic acid,2, 4-dinitrochlorobenzene,Inflammation,Oxidative stress

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