Amycolatolides A and B: Two New Secondary Metabolites from the Lichen-Derived Actinomycete Amycolatopsis Sp. YIM 130923

Two new secondary metabolites, amycolatolides A (1) and B (2), along with twelve known compounds (3-14), were isolated from the fermentation products of lichen-derived Amycolatopsis sp. YIM 130923. The structures of 1 and 2 were elucidated on the basis of NMR spectroscopic and HRESI-MS analysis. Meanwhile, the absolute configuration of 1 was deduced by X-ray diffraction analysis. Furthermore, compound 3 was obtained from microbial resources for the first time, 13 and 14 were firstly found from the genus Amycolatopsis. Some of the isolated compounds were evaluated for their antimicrobial activities by broth microdilution method. The results showed that compound 14 possessed moderate antifungal activities against Fusarium graminearum and Aspergillus niger with MIC values of 16 and 32 mu g/mL, respectively.