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Associations of HPV-16 Gene Methylation with Oral HPV-16 Persistence among a Multinational Sample of Men

Jessica Y Islam,Deepti Bettampadi,Richard R Reich,Belinda Nedjai,Anna R Giuliano

Sexually transmitted diseases（2023）

Cited 0|Views23
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Abstract
Abstract Using data from the Human Papillomavirus (HPV) Infection in Men cohort study, we demonstrate HPV-16 methylation associations with persistent oral HPV infection, the obligate precursor to oropharyngeal cancer. Human papillomavirus type 16 persistence was significantly associated with methylation of HPV-16 L2 CpG-4268 (Wilcoxon P = 0.04), and methylation of HPV-16 E2 CpG Pos 4 (Wilcoxon P = 0.04).
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