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    • Harnessing the Noncanonical Keap1-Nrf2 Pathway for Human Cytomegalovirus Control

    Ayan K. Ghosh,Yu-Pin Su,Michael Forman,Robert F. Keyes,Brian C. Smith,Xin Hu,Marc Ferrer,Ravit Arav-Boger

    Journal of virology（2023）SCI 2区SCI 1区

    Med Coll Wisconsin | Johns Hopkins Univ | NCATS

    Cited 1|Views35
    Abstract
    Antiviral treatment for human cytomegalovirus (HCMV) is limited and suffers from the selection of drug-resistant viruses. Several cellular pathways have been shown to modulate HCMV replication.
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    human cytomegalovirus,noncanonical Keap1-Nrf2 pathway,SQSTM1,p62,antioxidant response element,ARP101,p62-Keap1-Nrf2
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    【要点】：本文探讨了利用非常规的Keap1-Nrf2通路来控制人类巨细胞病毒（HCMV）的复制，以应对现有抗病毒治疗药物的限制和耐药性问题。
    

    【方法】：研究通过细胞培养和分子生物学技术，分析了Keap1-Nrf2通路在HCMV复制中的作用。
    

    【实验】：实验在HCMV感染的细胞中进行，通过激活Keap1-Nrf2通路，观察到病毒复制受到抑制，使用的数据集包括HCMV感染细胞的相关生物学参数，结果显示该通路具有潜在的抑制HCMV复制的作用。