Cation/proton antiporters: novel structure-driven pharmaceutical opportunities.
Trends in pharmacological sciences(2023)
摘要
Cation/proton antiporters (CPAs) regulate cells' salt concentration and pH. Their malfunction is associated with a range of human pathologies, yet only a handful of CPA-targeting therapeutics are presently in clinical development. Here, we discuss how recently published mammalian protein structures and emerging computational technologies may help to bridge this gap.
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关键词
cation/proton antiporters,computational biology,pharmacology
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