The 'hit-and-run' strategy and viral carcinogenesis.

Future OncologyAhead of Print CommentaryThe ‘hit-and-run’ strategy and viral carcinogenesisAngioletta Lasagna, Irene Cassaniti, Paolo Sacchi, Simone Figini, Fausto Baldanti, Raffaele Bruno & Paolo PedrazzoliAngioletta Lasagna *Author for correspondence: Tel.: +39 382 502 544; E-mail Address: a.lasagna@smatteo.pv.ithttps://orcid.org/0000-0002-9611-1164Medical Oncology Unit, Fondazione IRCCS Policlinico San Matteo, Viale Camillo Golgi 19, Pavia, 27100, ItalySearch for more papers by this author, Irene CassanitiDepartment of Microbiology & Virology, Fondazione IRCCS Policlinico San Matteo, Viale Camillo Golgi 19, Pavia, 27100, ItalySearch for more papers by this author, Paolo SacchiDivision of Infectious Diseases I, Fondazione IRCCS Policlinico San Matteo, Viale Camillo Golgi 19, Pavia, 27100, ItalySearch for more papers by this author, Simone FiginiMedical Oncology Unit, Fondazione IRCCS Policlinico San Matteo, Viale Camillo Golgi 19, Pavia, 27100, ItalySearch for more papers by this author, Fausto BaldantiDepartment of Microbiology & Virology, Fondazione IRCCS Policlinico San Matteo, Viale Camillo Golgi 19, Pavia, 27100, ItalyDepartment of Clinical Surgical Diagnostic & Pediatric Sciences, University of Pavia, Viale Camillo Golgi 19, Pavia, 27100, ItalySearch for more papers by this author, Raffaele BrunoDivision of Infectious Diseases I, Fondazione IRCCS Policlinico San Matteo, Viale Camillo Golgi 19, Pavia, 27100, ItalyDepartment of Clinical Surgical Diagnostic & Pediatric Sciences, University of Pavia, Viale Camillo Golgi 19, Pavia, 27100, ItalySearch for more papers by this author & Paolo PedrazzoliMedical Oncology Unit, Fondazione IRCCS Policlinico San Matteo, Viale Camillo Golgi 19, Pavia, 27100, ItalyDeptartment of Internal Medicine & Medical Therapy, University of Pavia, Viale Camillo Golgi 19, Pavia, 27100, ItalySearch for more papers by this authorPublished Online:15 Mar 2023https://doi.org/10.2217/fon-2022-1171AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: cancerEBVHBVherpes virushit-and-runvaccinationviral infectionviromePapers of special note have been highlighted as: • of interest; •• of considerable interestReferences1. Liang G, Bushman FD. The human virome: assembly, composition and host interactions. Nat. Rev. Microbiol. 19, 514–527 (2021).Crossref, Medline, CAS, Google Scholar2. Massimino L, Lovisa S, Antonio Lamparelli L, Danese S, Ungaro F. Gut eukaryotic virome in colorectal carcinogenesis: is that a trigger? Comput. Struct. Biotechnol. J. 19, 16–28 (2020).Crossref, Medline, Google Scholar3. Clinton NA, Hameed SA, Agyei EK, Jacob JC, Oyebanji VO, Jabea CE. Crosstalk between the intestinal virome and other components of the microbiota, and its effect on intestinal mucosal response and diseases. J. Immunol. Res. 2022, 7883945 (2022). • A very useful update on the virome and diseases.Crossref, Medline, Google Scholar4. Lim ES, Zhou Y, Zhao G et al. Early life dynamics of the human gut virome and bacterial microbiome in infants. Nat. Med. 21, 1228–1234 (2015).Crossref, Medline, CAS, Google Scholar5. Broecker F, Moelling K. The roles of the virome in cancer. Microorganisms 9(12), 2538 (2021).Crossref, Medline, CAS, Google Scholar6. Tomaić V. Functional roles of E6 and E7 oncoproteins in HPV-induced malignancies at diverse anatomical sites. Cancers 8, 95 (2016).Crossref, Medline, Google Scholar7. Migliaro M, Massuh D, Infante MF, Brahm AM, San Martín MT, Ortuño D. Role of Epstein–Barr virus and human papilloma virus in the development of oropharyngeal cancer: a literature review. Int. J. Dent. 2022, 3191569 (2022).Crossref, Medline, Google Scholar8. Wang H, Chen XL, Liu K et al. Associations between gastric cancer risk and virus infection other than Epstein–Barr virus: a systematic review and meta-analysis based on epidemiological studies. Clin. Transl. Gastroenterol. 11, e00201 (2020).Crossref, Medline, Google Scholar9. Sasivimolrattana T, Chantratita W, Sensorn I, Chaiwongkot A, Oranratanaphan S, Bhattarakosol P. Human virome in cervix controlled by the domination of human papillomavirus. Viruses 14(9), 2066 (2022).Crossref, Medline, CAS, Google Scholar10. Foy JP, Bertolus C, Boutolleau D, Agut H, Gessain A, Herceg Z et al. Arguments to support a viral origin of oral squamous cell carcinoma in non-smoker and non-drinker patients. Front. Oncol. 10, 822 (2020).Crossref, Medline, Google Scholar11. Ferreira DA, Tayyar Y, Idris A, McMillan NAJ. A ‘hit-and-run’ affair – a possible link for cancer progression in virally driven cancers. Biochim. Biophys. Acta Rev. Cancer 1875(1), 188476 (2021). •• A very useful update on the current knowledge of hit-and-run strategy.Crossref, Medline, CAS, Google Scholar12. Galloway DA, McDougall JK. The oncogenic potential of herpes simplex viruses: evidence for a ‘hit-and-run’ mechanism. Nature 302(5903), 21–24 (1983).Crossref, Medline, CAS, Google Scholar13. Nevels M, Tauber B, Spruss T, Wolf H, Dobner T. ‘Hit-and-run’ transformation by adenovirus oncogenes. J. Virol. 75(7), 3089–3094 (2001).Crossref, Medline, CAS, Google Scholar14. Baker SC, Mason AS, Slip RG, Skinner KT, Macdonald A, Masood O et al. Induction of APOBEC3-mediated genomic damage in urothelium implicates BK polyomavirus (BKPyV) as a hit-and-run driver for bladder cancer. Oncogene 41(15), 2139–2151 (2022).Crossref, Medline, CAS, Google Scholar15. Arbach H, Viglasky V, Lefeu F, Guinebretière JM, Ramirez V, Bride N et al. Epstein–Barr virus (EBV) genome and expression in breast cancer tissue: effect of EBV infection of breast cancer cells on resistance to paclitaxel (Taxol). J. Virol. 80(2), 845–853 (2006).Crossref, Medline, CAS, Google Scholar16. Arias-Calvachi C, Blanco R, Calaf GM, Aguayo F. Epstein–Barr virus association with breast cancer: evidence and perspectives. Biology (Basel) 11(6), 799 (2022).Medline, CAS, Google Scholar17. Lung ML, Lam WK, So SY, Lam WP, Chan KH, Ng MH. Evidence that respiratory tract is major reservoir for Epstein–Barr virus. Lancet 1, 889–892 (1985).Crossref, Medline, CAS, Google Scholar18. Ambinder RF. Gammaherpesviruses and ‘hit-and-run’ oncogenesis. Am. J. Pathol. 156, 1–3 (2000).Crossref, Medline, CAS, Google Scholar19. Siciliano MC, Tornambè S, Cevenini G, Sorrentino E, Granai M, Giovannoni G et al. EBV persistence in gastric cancer cases conventionally classified as EBER-ISH negative. Infect. Agent. Cancer 17(1), 57 (2022).Crossref, Medline, CAS, Google Scholar20. Beller L, Matthijnssens J. What is (not) known about the dynamics of the human gut virome in health and disease. Curr. Opin. Virol. 37, 52–57 (2019).Crossref, Medline, Google ScholarFiguresReferencesRelatedDetails Ahead of Print eToC Sign up Follow us on social media for the latest updates Metrics Downloaded 9 times History Received 23 November 2022 Accepted 31 January 2023 Published online 15 March 2023 Information© 2023 Future Medicine LtdKeywordscancerEBVHBVherpes virushit-and-runvaccinationviral infectionviromeAuthor contributionsThe authors contributed equally to the present manuscript. All authors approved the submitted version of the manuscript.Financial & competing interests disclosureThe authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.No writing assistance was utilized in the production of this manuscript.Take home messageThe role of the virome in controlling immunity and diseases has achieved interest in recent years. Viruses have been demonstrated as inducers of tumorigenesis. Progressively the studies have suggested links between virus, dysbiosis and cancer, although a direct causal relationship has not yet been demonstrated for the majority of cancers. In the past, only the presence of the virus in the tumor suggested a causal relationship. This may have led to an underestimation of the number and types of virus-induced cancers resulting in new preventive and therapeutic horizons.PDF download