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Exome Sequencing Identifies Rare Mutations of LDLR and QTRT1 Conferring Risk for Early-Onset Coronary Artery Disease in Chinese

Kang Yao,Yuxiang Dai,Juan Shen,Yi Wang,Huanjie Yang,Runda Wu,Qijun Liao,Hongyi Wu,Xiaodong Fang,Shalaimaiti Shali,Lili Xu,Meng Hao,Chenhao Lin,Zhonghan Sun,Yilian Liu, Mengxin Li,Zhen Wang, Qiang Gao,Shuning Zhang,Chenguang Li,Wei Gao,Lei Ge,Yunzeng Zou,Aijun Sun,Juying Qian,Li Jin,Shangyu Hong,Yan Zheng,Junbo Ge

National Science Review（2022）

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摘要
Despite the advances made over the past decades,the known loci for coronary artery disease(CAD)still only explain＜20％of the genetic variation in risk[1,2].
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Atherosclerotic Cardiovascular Risk
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