Oxygen Treatment Reduces Neurological Deficits and Demyelination in Two Animal Models of Multiple Sclerosis.

Mario Amatruda,Kate Harris, Alina Matis,Andrew L. Davies,Daniel McElroy, Michael Clark,Christopher Linington,Roshni Desai,Kenneth J. Smith

Neuropathology & applied neurobiology/Neuropathology and applied neurobiology（2023）

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摘要

The objective of the study is to explore the importance of tissue hypoxia in causing neurological deficits and demyelination in the inflamed CNS, and the value of inspiratory oxygen treatment, using both active and passive experimental autoimmune encephalomyelitis (EAE).

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EAE,hypoxia,integrated stress response,neuroinflammation,oxidative damage,oxygen treatment

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