A Novel Human Ipsc Model of COL4A1/A2 Small Vessel Disease Unveils a Key Pathogenic Role of Matrix Metalloproteinases.

Maha Al-Thani,Mary Goodwin-Trotman,Steven Bell, Krushangi Patel,Lauren K. Fleming,Catheline Vilain,Marc Abramowicz,Stuart M. Allan,Tao Wang,M. Zameel Cader,Karen Horsburgh,Tom Van Agtmael,Sanjay Sinha,Hugh S. Markus,Alessandra Granata

Stem Cell Reports（2023）

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Key words

Cerebral small vessel disease,COL4A1/A2,blood-brain barrier,human induced pluripotent stem cells,disease modelling,mural cells,endothelial cells,extracellular matrix,matrix metalloproteinases

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