Connexin 43-modified bone marrow stromal cells reverse the imatinib resistance of K562 cells via Ca 2+ -dependent gap junction intercellular communication.

Xiaoping Li,Yunshuo Xiao,Xiaoqi Wang,Ruihao Huang,Rui Wang,Yi Deng,Jun Rao,Qiangguo Gao,Shijie Yang,Xi Zhang

Chinese medical journal（2023）

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摘要

Cx43 deficiency exists in CML patients, promoting the generation of MRD and inducing drug resistance. Enhancing Cx43 expression and GJIC function in the HM may be a novel strategy to reverse drug resistance and promote IM efficacy.

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