FIGURE 6 from Exploring the Onset and Progression of Prostate Cancer Through a Multicellular Agent-based Model

Effect on tumor growth of varying sensitive model parameters. A, Grouped histogram of the repeated sensitivity analysis (five times for each parameter), overlapped by four (differently colored) histograms of the most sensitive parameters: mutation probability of luminal cells (Pmut, red), probability of CAFs promoting tumor cell proliferation (CFprom, green), yellow represents the amount of mutations needed before tumor cells affect macrophage differentiation (TUthrshM) and M1 macrophage migration probability (M1pmig, blue). B, The averaged evolution of the amount of tumor cells for 40 simulations that developed cancer for each of the eight subclasses. These classes were based on the “high” or “low” status of sensitive parameters for CAFs, TAMs, and tumor cells. Included is a violin plot depicting the spread of simulated tumor cell amounts. C, An example of tumor development for each group at an early point in the simulation (50 days), the point at which it becomes invasive and the state at the end of the simulation (400 days).