Dysregulation of Mitochondrial Translation Caused by CBFB Deficiency Cooperates with Mutant PIK3CA and Is a Vulnerability in Breast Cancer.

Navdeep Malik,Young-Im Kim,Hualong Yan,Yu-Chou Tseng,Wendy du Bois,Gamze Ayaz,Andy D Tran,Laura Vera-Ramirez,Howard Yang,Aleksandra M Michalowski,Michael Kruhlak,Maxwell Lee,Kent W Hunter,Jing Huang

Cancer research（2023）

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摘要

CBFB-regulated mitochondrial translation is a regulatory step in breast cancer metabolism and synergizes with mutant PI3K in breast cancer progression.

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关键词

mitochondrial translation,mutant pik3ca,breast cancer,deficiency cooperates

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