Depleting Hepatitis B Virus Relaxed Circular DNA is Necessary for Resolution of Infection by CRISPR-Cas9

Dmitry Kostyushev,Anastasiya Kostyusheva,Sergey Brezgin,Natalia Ponomareva,Natalia F. Zakirova,Aleksandra Egorshina,Dmitry V. Yanvarev,Ekaterina Bayurova, Anna Sudina,Irina Goptar,Anastasiya Nikiforova, Elena Dunaeva,Tatiana Lisitsa,Ivan Abramov,Anastasiia Frolova,Alexander Lukashev,Ilya Gordeychuk,Andrey A. Zamyatnin Jr,Alexander Ivanov,Vladimir Chulanov

Molecular therapy Nucleic acids（2023）

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关键词

MT: RNA/DNA Editing,reverse transcription,Cas9 RNPs,cccDNA elimination,chronic hepatitis B,epigenetics,DNA methylation,viral rebound,cure,antiviral therapy

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