High prevalence and mortality of Pneumocystis jirovecii pneumonia in anti-MDA5 antibody-positive dermatomyositis.

Xixia Chen,Xiaoming Shu,Linrong He,Hanbo Yang,Xin Lu,Guochun Wang,Yongpeng Ge

Rheumatology (Oxford, England)（2023）

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Abstract

PJP has high prevalence and mortality in anti-MDA5+ DM. It is crucial for clinicians to identify high-risk patients and promptly institute TMP/SMZ to prevent PJP. mNGS is the preferred approach for pathogen detection in anti-MDA5+ DM when PJP is suspected.

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Key words

Pneumocystis jirovecii pneumonia,anti-MDA5 antibody,dermatomyositis,metagenomic next-generation sequencing,opportunistic infections

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