Molten Globule Driven and Self-downmodulated Phase Separation of a Viral Factory Scaffold

Mariano Salgueiro, Gabriela Camporeale,Araceli Visentin, Martin Aran,Leonardo Pellizza, Sebastián A. Esperante,Agustín Corbat, Hernán Grecco, Belén Sousa, Ramiro Esperón, Silvia S. Borkosky,Gonzalo de Prat-Gay

Journal of Molecular Biology（2023）

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摘要

•Biophysical principles of RSV virus factory assembly and modulation need to be elucidated.•RSV-P is the scaffold for biomolecular condensation both in vitro and in cells.•RSV-P restores nucleoprotein aggregates into liquid droplets.•RSV-P may act as the “solvent protein” within the viral factories.

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viral factory scaffold,phase separation,self-downmodulated

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