Editorial: Neural immuno-inflammatory response in neurodegenerative diseases

Neurodegeneration from Alzheimer's disease (AD), Parkinson's disease (PD), stroke, neurotrauma, 7 and other brain diseases could lead to dementia and severe cognitive disorders. In all these 8 conditions, the cellular and molecular mechanisms underlying the occurrence and development of 9 neurodegeneration are expected to be fully elucidated. These mechanisms include immune 10 regulation, chronic inflammatory response, production and deposition of pathological proteins, 11 blood-brain barrier damage, etc ( neurobiological basis for further investigation of potential treatments was also described. 60While the five articles have broadened our previous understanding on the roles of neural immuno-61 inflammatory response and its regulatory mechanism in various neurodegenerative diseases, its 62 associated intervention strategies still remain to be studied. Further research from in-vitro to in-vivo 63 models is needed to be designed using novel bio-techniques, such as single cell sequencing and 64 spatial transcriptomics, aiming at exploring effective treatments for clinical application.