Clearance of Plasma PCSK9 Via the Asialoglycoprotein Receptor Mediated by Heterobifunctional Ligands

Jeffrey T. Bagdanoff,Thomas M. Smith, Martin Allan, Peter O'Donnell, Zachary Nguyen, Elizabeth A. Moore,Jason Baird, Shuangxi Wang,Vanitha Subramanian,Bruno Tigani,David O. Nettleton,Lauren G. Monovich,Ian Lewis,Alec N. Flyer,Brian Granda,John W. Blankenship,David Barnes-Seeman,Kevin B. Clairmont

CELL CHEMICAL BIOLOGY（2023）

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关键词

Proprotein convertase subtilisin/kexin type 9,PCSK9,low density lipoprotein,LDL,low density lipoprotein receptor,LDLR,asialoglycoprotein receptor,ASGPR,targeted protein degradation,TPD,targeted plasma protein degradation,TPPD,endosome,endolysosome,lysosome,lysosome targeting chimera,LYTAC

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