Molecular Mechanocytometry Using Tension-activated Cell Tagging (TaCT)
Nature methods(2023)
摘要
Flow cytometry is routinely used to measure single-cell gene expression by staining cells with fluorescent antibodies and nucleic acids. Here we present Tension-activated Cell Tagging (TaCT) to fluorescently label cells based on the magnitude of molecular force transmitted through cell adhesion receptors. As a proof-of-concept, we analyzed fibroblasts and mouse platelets after TaCT using conventional flow cytometry.
### Competing Interest Statement
The authors have declared no competing interest.
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