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    • Putting PLX5622 into Perspective: Microglia in Central Nervous System Viral Infection

    Alanna G. Spiteri,Nicholas J. C. King

    Neural Regeneration Research（2023）SCI 2区

    Viral Immunopathology Laboratory

    Cited 5|Views0
    Abstract
    Elucidating the exact contribution of microglia to central nervous system(CNS)pathology has historically been extremely challenging.These resident parenchymal myeloid cells are considered to have critical roles as frontline responders during pathogen invasion and CNS perturbation.
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    Microglia
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    • Pretraining has recently greatly promoted the development of natural language processing (NLP)
    • We show that M6 outperforms the baselines in multimodal downstream tasks, and the large M6 with 10 parameters can reach a better performance
    • We propose a method called M6 that is able to process information of multiple modalities and perform both single-modal and cross-modal understanding and generation
    • The model is scaled to large model with 10 billion parameters with sophisticated deployment, and the 10 -parameter M6-large is the largest pretrained model in Chinese
    • Experimental results show that our proposed M6 outperforms the baseline in a number of downstream tasks concerning both single modality and multiple modalities We will continue the pretraining of extremely large models by increasing data to explore the limit of its performance
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    【要点】：论文探讨了微胶质细胞在中枢神经系统病毒感染中的确切作用，并强调了PLX5622在研究中的作用，揭示了其作为一线响应者的关键角色。
    

    【方法】：通过综述现有研究，分析了微胶质细胞在CNS病毒感染中的功能及PLX5622对微胶质细胞的影响。
    

    【实验】：文中未具体描述实验过程及使用的数据集，主要侧重于理论分析和文献综述。