HEADACHE ASSOCIATED WITH EXCESSIVE USAGE OF ANALGESICS: CLINICAL-PSYCHOLOGICAL AND NEUROPHYSIOLOGICAL ANALYSIS, AND SPECIFICS OF THE PERIOD OF THE PERIOD OF DRUG WITHDRAWAL

According to epidemiological studies, in developed countries from 1 to 2% of the population suffering from headache associated with the abuse of analgesics. The lack of a structured understanding of the abuse headache pathogenesis, the difficulty of well-timed diagnostics and choice of effective treatment resulting of the relapse in 30-50% within 1-5 years. The aim of the study was to investigate the clinical and psycho-physiological characteristics of abuse headache and during the period of withdrawal abuse medication with "detoxification" therapy. According to the study, most patients with abuse headache abused combined analgesics (88%). We are observed a statistically-valid higher level of drug dependence, reactive and personal anxiety, depression and sleep disorders in patients with abuse headache. Development of drug withdrawal period was different in the groups with migraine and tension-type headache (lower intensity of headache was observed in the group with migraines), as well as in groups with one-stage and gradual drug withdrawal (headache course with one-stage withdrawal clinically was more easily). Increase in the overall amplitude response N75/P100, with an emphasis in the period of drug withdrawal and lack of habituation N75/P100 in patients with AGB were detected. This may indicate the increase in cortical excitability due to reducing the inhibitory thalamo-cortical and intracortical influences. Analysis of the results proves the effectiveness of the usage «detoxification» therapy in the acute phase of abuse drug withdrawal, and gives reason to recommend it to practical use in conjunction with the prescription of preventive treatment.