Several Posttranslational Modifications Act in Concert to Regulate Gephyrin Scaffolding and GABAergic Transmission

Himanish Ghosh, Luca Auguadri,Sereina Battaglia,Zahra Simone Thirouin,Khaled Zemoura,Simon Messner,Mario A. Acuña,Hendrik Wildner,Gonzalo E. Yévenes, Andrea Dieter,Hiroshi Kawasaki,Michael O. Hottiger,Hanns Ulrich Zeilhofer,Jean-Marc Fritschy,Shiva K. Tyagarajan

Nature Communications（2016）

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摘要

Gephyrin is a cytoplasmic scaffolding protein that selectively forms postsynaptic scaffolds at GABAergic and glycinergic synapses. Here the authors characterize regulatory mechanisms determining gephyrin scaffolding and GABAA receptor synaptic transmission that involve acetylation, SUMOylation and phosphorylation.

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SUMOylation

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