Genetic Recombination of Orientia Tsutsugamushi Strains from Scrub Typhus Patients in Guangxi, Southwest China, and the Analysis of Clinical Features.
MICROBES AND INFECTION(2023)
摘要
Three Orientia tsutsugamushi genotypic groups belonging to two prototypes (Gilliam and Karp) were identified in scrub typhus patients from Guangxi, Southwest China. Fever, headache, pneumonia, fatigue, chill, and anorexia were the most common clinical signs. Frequent recombination was observed for their 47-kDa gene compared to 56-kDa and 16S genes. Furthermore, patients infected with the Gilliam prototype represent a much higher proportion of pneumonia (6/6, 100%) than those infected with the Karp prototype (4/8, 50%) (p-value = 0.040). This discrepancy is consistent with recent animal tests on rhesus and may indicate different virulence and tissue tropism between different O. tsutsugamushi prototypes.
更多查看译文
关键词
Scrub typhus,Orientia tsutsugamushi,Recombination,Gilliam prototype,Pneumonia
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要