Amoxicillin and penicillin G dosing in pediatric community-acquired pneumococcal pneumonia in the era of conjugate pneumococcal vaccines.

Dustin Huynh,Norint Tung,Quang Dam,Tri Tran,Kristina G. Hulten,Christopher J. Harrison,Sheldon L. Kaplan,Tyler H. Do,Amartya Setty,Jennifer Le

Pharmacotherapy（2022）

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摘要

Based on the recent rates of resistance, antibiotic doses evaluated provide appropriate exposure for pediatric CAP based on the serum and ELF data associated with predicted clinical and microbiologic success for pneumococcus. High-dose AMOX may still be required to treat pediatric CAP, especially if using CLSI breakpoints. Ongoing surveillance for resistance is essential.

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关键词

Streptococcus pneumoniae ,Monte Carlo simulation,beta-lactams,children,pharmacodynamic,pneumococcal vaccine,pneumonia

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