Engineered Human Antibody with Improved Endothelin Receptor Type A Binding Affinity, Developability, and Serum Persistence Exhibits Excellent Antitumor Potency.

Sanghwan Ko,Man-Seok Ju,Hye-Mi Ahn,Jung-Hyun Na, Woo Hyung Ko,Migyeong Jo,Munsu Kyung,Chung Su Lim,Byoung Joon Ko,Won-Kyu Lee,Youn-Jae Kim,Sang Taek Jung

Molecular pharmaceutics（2022）

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Key words
G protein-coupled receptor,endothelin receptor,antibody therapeutics,antibody engineering,anticancer potency
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