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Perphenazine–Macrocycle Conjugates Rapidly Sequester the Aβ42 Monomer and Prevent Formation of Toxic Oligomers and Amyloid

Sarah R. Ball,Julius S. P. Adamson,Michael A. Sullivan,Manuela R. Zimmermann,Victor Lo,Maximo Sanz-Hernandez,Xiaofan Jiang,Ann H. Kwan,Andre D. J. McKenzie,Eryn L. Werry,Tuomas P. J. Knowles,Michael Kassiou,Georg Meisl,Matthew H. Todd,Peter J. Rutledge,Margaret Sunde

ACS chemical neuroscience（2022）

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关键词
amyloid,Alzheimer's disease,monomer sequestration,oligomers,inhibition,kinetic analysis
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