Hemodynamic impacts of apelin-13 in a neonatal lamb model of septic peritonitis
Pediatric research(2022)
摘要
Background Apelins are potential candidate therapeutic molecules for hemodynamic support. The objective of this study was to assess the hemodynamic impacts of apelin-13 in a neonatal lamb model of septic shock. Methods Lambs were randomized to receive apelin-13 or normal saline. Septic shock was induced by injecting a fecal slurry into the peritoneal cavity. Lambs underwent volume repletion (30 mL/kg over 1 h) followed by intravenous administration of 5 incremental doses (D) of apelin-13 (D1 = 0.039 to D5 = 19.5 µg/kg/h) or normal saline. Results Following fecal injection, mean arterial pressure (MAP) and cardiac index (CI) dropped in both groups ( p < 0.05). The MAP decreased non-significantly from D1 to D5 ( p = 0.12) in the saline group, while increasing significantly ( p = 0.02) in the apelin group (−12 (−17; 12) vs. +15 (6; 23) % ( p = 0.012)). Systemic vascular resistances were higher in the apelin-13 group at D5 compared to the saline group (4337 (3239, 5144) vs. 2532 (2286, 3966) mmHg/min/mL, respectively, p = 0.046). The CI increased non-significantly in the apelin-13 group. Conclusion Apelin-13 increased MAP in a neonatal lamb septic shock model. Impact Administration of apelin-13 stabilized hemodynamics during the progression of the sepsis induced in this neonatal lamb model. Systemic vascular resistances were higher in the apelin-13 group than in the placebo group. This suggests ontogenic differences in vascular response to apelin-13 and warrants further investigation. This study suggests that apelin-13 could eventually become a candidate for the treatment of neonatal septic shock.
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关键词
Medicine/Public Health,general,Pediatrics,Pediatric Surgery
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