Different Mechanisms Are Utilized by Coronavirus Transmissible Gastroenteritis Virus to Regulate Interferon Lambda 1 and Interferon Lambda 3 Production.
Journal of virology(2022)
摘要
Coronaviruses cause infectious diseases in various mammals and birds and exhibit an epithelial cell tropism in enteric and respiratory tracts. It is critical to explore how coronavirus infections modulate IFN-λ, a key innate cytokine against mucosal viral infection.
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关键词
coronavirus,type III IFN,RLR-mediated signaling,protein kinase R-like ER kinase,transmissible gastroenteritis virus,nonstructural protein 1 (nsp1),NF-kappa B
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