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Different Mechanisms Are Utilized by Coronavirus Transmissible Gastroenteritis Virus to Regulate Interferon Lambda 1 and Interferon Lambda 3 Production.

Journal of virology(2022)

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摘要
Coronaviruses cause infectious diseases in various mammals and birds and exhibit an epithelial cell tropism in enteric and respiratory tracts. It is critical to explore how coronavirus infections modulate IFN-λ, a key innate cytokine against mucosal viral infection.
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关键词
coronavirus,type III IFN,RLR-mediated signaling,protein kinase R-like ER kinase,transmissible gastroenteritis virus,nonstructural protein 1 (nsp1),NF-kappa B
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