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Primary Resistance to First- and Second-Generation ALK Inhibitors in a Non-Small Cell Lung Cancer Patient with Coexisting ALK Rearrangement and an ALK F1174L-cis-S1189C De Novo Mutation: A Case Report

Jiuzhou Zhao,Xiang Li, Ruizhe Fan,Yaping Qin,Zhizhong Wang,Bo Wang,Shaomei Li, Jianfeng Fan,Xinxin Wu, Hongxia Liu, Yuping Guan, Yinfeng Liang,Xiao Zhang,Yongjun Guo

Frontiers in pharmacology(2022)

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关键词
non-small cell lung cancer (NSCLC),next generation sequencing (NGS),EML4-ALK,F1174L,S1189C,de novo mutation
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