Targeting VEGF-A/VEGFR2 Y949 Signaling-Mediated Vascular Permeability Alleviates Hypoxic Pulmonary Hypertension.

Weibin Zhou,Keli Liu,Lei Zeng, Jiaqi He,Xinbo Gao,Xinyu Gu,Xun Chen,Jing Jing Li,Minghui Wang,Duoguang Wu,Zhixiong Cai,Lena Claesson-Welsh,Rong Ju,Jingfeng Wang,Feng Zhang,Yangxin Chen

Circulation（2022）

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摘要

Our results support the notion that VEGF-A/VEGFR2 Y949-dependent vascular permeability is an important determinant in the pathogenesis of PH and might serve as an attractive therapeutic target pathway for this disease.

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关键词

Src family kinase,VEGF-A,VEGFR2 Y949,hypoxic pulmonary hypertension,macrophage,single-cell RNA sequencing,smooth muscle,vascular permeability

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