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Design and rationale of a phase 1 dose-escalation study of AMG 193, a methylthioadenosine (MTA)-cooperative PRMT5 inhibitor, in patients with advanced methylthioadenosine phosphorylase (MTAP)-null solid tumors

Miguel Angel Villalona-Calero,Amita Patnaik,Robert G. Maki,Bert O'Neil,James L. Abbruzzese,Ibiayi Dagogo-Jack,Siddhartha Devarakonda, Sara Wahlroos,Chia-Chi Lin,Yutaka Fujiwara,Angelika Terbuch,Sophie Postel-Vinay,Maria-Elisabeth Goebeler,Alfredo Addeo,Hans Prenen,Tobias Arkenau,Adrian G. Sacher, Chunxu Liu,William Kormany, Jordi Rodon Ahnert

JOURNAL OF CLINICAL ONCOLOGY（2022）

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advanced methylthioadenosine phosphorylase,tumors,inhibitor,dose-escalation
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