Towards Refining the Utility of Dual (18F-FDG / 18F-Choline) PET/CT for the Management of Hepatocellular Carcinoma: a Tertiary Center Study

BACKGROUND: The role of positron emission tomography/computed tomography (PET/CT) in hepatocellular carcinoma (HCC) management is not clearly defined. Our objective was to analyze the utility of dual-PET/CT (F-18-FDG / F-18-Choline) imaging findings on the BCLC staging and treatment decision for HCC patients.METHODS: Between January 2011 and April 2019, 168 consecutive HCC patients with available baseline dual-PET/CT imaging data were retrospectively analyzed. To identify potential refinement criteria for surgically-treated patients, survival Kaplan-Meier curves of various standard of-care and dual-PET/CT baseline parameters were estimated. Finally, multivariate cox proportional hazard ratios of the most relevant clinico-biological and/or PET parameters were estimated.RESULTS: Dual-PET/CT findings increased the score of BCLC staging in 21 (12.5%) cases. In 24.4% (N.=41) of patients, the treatment strategy was modified by the PET findings. Combining AFP levels at a threshold of 10 ng/mL with F-18-FDG or F-18-Choline N status significantly impacted DFS (P<0.05). In particular, the combined criteria of the N+ status assessed by F-18-Choline with AFP threshold of 10 ng/mL provided a highly predictive composite parameter for estimation of DFS according to multivariate analysis (HR=10.6, P<0.05).CONCLUSIONS: The F-18-Choline / AFP composite parameter appears promising, and further prospective studies are mandatory to validate its oncological impact.