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Decoupling of Catalysis and Transition State Analog Binding from Mutations Throughout a Phosphatase Revealed by High- Throughput Enzymology

Craig J. Markin,Daniel A. Mokhtari,Siyuan Du,Tzanko Doukov,Fanny Sunden, Jordan A. Cook,Polly M. Fordyce,Daniel Herschlag

Proceedings of the National Academy of Sciences（2023）

Cited 1|Views23
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Key words
enzyme catalysis,transition state specificity,transition state analogs,high-throughput biochemistry,conformational ensembles
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