Surface Labeling of Enveloped Virus with Polymeric Imidazole Ligand-Capped Quantum Dots Via the Metabolic Incorporation of Phospholipids into Host Cells
Journal of materials chemistry B(2016)
摘要
We report a general method for the preparation of quantum dot-labeled viruses through a strain-promoted azide-alkyne cycloaddition (SPAAC) reaction. The quantum dot sample was functionalized with methacrylate-based polymeric imidazole ligands (MA-PILs) bearing dibenzocyclooctyne groups. Enveloped measles virus was labeled with azide groups through the metabolic incorporation of a choline analogue into the host cell membrane, and then linked with the modified QDs. The virus retained its infectious ability against host cells after the modification with MA-PIL capped QDs.
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