Prognostic impact of unsupervised early assessment of bulk and leukemic stem cell measurable residual disease in acute myeloid leukemia.

Alban Canali,Inès Vergnolle,Sarah Bertoli,Laetitia Largeaud, Marie-Laure Nicolau,Jean-Baptiste Rieu,Suzanne Tavitian,Francoise Huguet,Muriel Picard,Pierre Bories,Jean-Philippe Vial,Nicolas Lechevalier,Marie-Christine Béné,Isabelle Luquet,Véronique Mansat-De Mas,Eric Delabesse,Christian Recher,Francois Vergez

Clinical cancer research : an official journal of the American Association for Cancer Research（2022）

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摘要

In this study, we confirm the prognostic impact of post-induction MFC Bulk MRD in AML patients. Focusing on LSCs, we identified a group of patients with negative Bulk MRD but positive LSC MRD (25.8% of our cohort) with an intermediate prognosis, demonstrating the interest of MRD analysis focusing on leukemic chemoresistant subpopulations.

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关键词

acute myeloid leukemia,unsupervised early assessment

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