Germinal Center B Cells That Acquire Nuclear Proteins Are Specifically Suppressed by Follicular Regulatory T Cells
eLife(2023)
Univ Michigan Ann Arbor | Indiana Univ Sch Med | Osaka University
Abstract
Follicular regulatory T cells (Tfr) restrict development of autoantibodies and autoimmunity while supporting high-affinity foreign antigen-specific humoral response. However, whether Tfr can directly repress germinal center (GC) B cells that acquire autoantigens is unclear. Moreover, TCR specificity of Tfr to self-antigens is not known. Our study suggests that nuclear proteins contain antigens specific to Tfr. Targeting of these proteins to antigen-specific B cells in mice triggers rapid accumulation of Tfr with immunosuppressive characteristics. Tfr then exert negative regulation of GC B cells with predominant inhibition of the nuclear protein-acquiring GC B cells, suggesting an important role of direct cognate Tfr-GC B cells interactions for the control of effector B cell response.
MoreTranslated text
Key words
Memory T Cells,T Cell Immunity
PDF
View via Publisher
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Related Papers
Cold-blooded Vertebrates Evolved Organized Germinal Center–like Structures
SCIENCE IMMUNOLOGY 2023
被引用7
Proceedings of the National Academy of Sciences 2024
被引用0
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn
Chat Paper
去 AI 文献库 对话