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Germinal Center B Cells That Acquire Nuclear Proteins Are Specifically Suppressed by Follicular Regulatory T Cells

eLife(2023)

Univ Michigan Ann Arbor | Indiana Univ Sch Med | Osaka University

Cited 3|Views22
Abstract
Follicular regulatory T cells (Tfr) restrict development of autoantibodies and autoimmunity while supporting high-affinity foreign antigen-specific humoral response. However, whether Tfr can directly repress germinal center (GC) B cells that acquire autoantigens is unclear. Moreover, TCR specificity of Tfr to self-antigens is not known. Our study suggests that nuclear proteins contain antigens specific to Tfr. Targeting of these proteins to antigen-specific B cells in mice triggers rapid accumulation of Tfr with immunosuppressive characteristics. Tfr then exert negative regulation of GC B cells with predominant inhibition of the nuclear protein-acquiring GC B cells, suggesting an important role of direct cognate Tfr-GC B cells interactions for the control of effector B cell response.
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Memory T Cells,T Cell Immunity
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要点】:该论文发现滤泡调节T细胞(Tfr)能够直接抑制获取核蛋白的生发中心B细胞,防止自身抗体的发育,同时支持高亲和力外源抗原特异性体液反应,揭示了一种新的自身免疫调节机制。

方法】:研究通过将核蛋白靶向至特定抗原的B细胞,观察Tfr细胞的积累和其免疫抑制特性,进而分析Tfr对生发中心B细胞的调节作用。

实验】:在实验中,研究者使用小鼠模型,通过靶向核蛋白至抗原特异性B细胞,发现能够迅速积累具有免疫抑制特性的Tfr细胞,这些Tfr细胞对获取核蛋白的生发中心B细胞产生了显著的负调节作用,实验结果支持了Tfr与生发中心B细胞直接相互作用在控制效应B细胞反应中的重要作用。具体的数据集名称在文中未提及。