Heliangin acts as a covalent ligand of RPS2 that disrupts pre-rRNA metabolic processes in NPM1 -mutated acute myeloid leukemia.
Acta pharmaceutica Sinica. B（2023）
关键词
Acute myeloid leukemia,Covalent,Differentiation,Heliangin,NPM1-mutation,Pre-rRNA,RPS2,p53 stabilization
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