Overcoming Preclinical Safety Obstacles to Discover (S)-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor

Michael J. Townsend,Craig E. Stivala,Christopher McBride,Lynnie Trzoss,Davide Povero,Milos Lazic,Geza Ambrus-Aikelin,Angelina Santini,Rama Pranadinata, Gretchen Bain,Ryan Stansfield,Jeffrey A. Stafford, James Veal,Ryan Takahashi,Justin Ly, Shu Chen,Liling Liu,Marika Nespi,Robert Blake,Arna Katewa,Tracy Kleinheinz,Swathi Sujatha-Bhaskar,Nandhini Ramamoorthi,Jessica Sims,Brent McKenzie,Mark Chen,Mark Ultsch, Matthew Johnson,Jeremy Murray,Claudio Ciferri,Steven T. . Staben

Journal of Medicinal Chemistry（2022）

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