Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer

Lele Song, Xinyi Yao,Hangpeng Li,Bo Peng,Alan P. Boka,Yiman Liu,Guochao Chen, Zhenyang Liu, Kaeli M. Mathias,Lingbo Xia,Qinglan Li,Mustafa Mir,Yuanyuan Li,Haitao Li,Liling Wan

Molecular Cell（2022）

引用 29|浏览36

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关键词

cancer epigenetics,mutations,chromatin reader,ENL YEATS,transcriptional condensates/hubs,phase separation,structured domains,intrinsically disordered protein region,IDR,multivalent interactions,transcription elongation

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