Advancement and Authentication of Spectrophotometric Method for Detection of Losartan Potassium

A quick, accurate, and cost-effective method for measuring Losartan potassium (LP) has been established using a UV spectrophotometer. This method was designed to measure the amount of LP released from transdermal drug delivery systems using phosphate buffer solution pH 7.4 (Saline phosphate buffer). The wavelength maximum (λmax) of losartan potassium is 205nm in phosphate buffer with a pH of 7.4. The proposed UV spectroscopic method exhibited linearity in the range of 1–5µg/ml and was confirmed in terms of linearity, specificity, accuracy (recovery), and precision as per International Conference on Harmonization (ICH) guidelines with a correlation coefficient (R2) of 0.998. Recovery test and statistical validation of the research findings revealed the suitability of the developed method for routine analysis of losartan potassium in transdermal formulations. Hence, the suggested method for estimating losartan potassium from transdermal drug delivery systems was simple, accurate and efficient.