One-Dimensional Simultaneous Achiral and Chiral Analysis

Most molecules with therapeutic value have at least one chiral center, requiring resolution of both achiral and chiral impurities. Separate achiral and chiral methods are the most used methodologies, but two-dimensional (2D) methods and columns in series have also been implemented. Having a mixed-mode column that can provide both achiral and chiral resolution in one-dimension (1D) would significantly improve impurity profile understanding and reduce testing workload.